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Lincolnshire Knee

23 Dec 2025

Arthrosamid for Bilateral Knee Osteoarthritis: Enhancing Mobility and Comfort When Both Knees Are Affected

Arthrosamid for Bilateral Knee Osteoarthritis: Enhancing Mobility and Comfort When Both Knees Are Affected

Bilateral knee osteoarthritis (OA) occurs when the cartilage in both knees gradually wears down, causing pain, stiffness, and reduced mobility. When both knees are affected, the challenges become greater, often impacting a person’s independence and day-to-day activities. Arthrosamid is an exciting new treatment designed to ease symptoms and improve comfort for those living with OA in both knees. In this article, we delve into the particular difficulties faced by people with bilateral knee OA and how Arthrosamid can help provide balanced and lasting relief, making movement easier and daily life more comfortable.

Understanding Bilateral Knee Osteoarthritis

Bilateral knee osteoarthritis means that both knees are affected by the breakdown of cartilage — the smooth tissue that cushions the joints. Unlike OA in just one knee, having both knees involved can make even simple movements more difficult and painful. Tasks such as walking steadily, climbing stairs, or standing for periods can become real challenges. This condition often disrupts daily routines and reduces a person’s ability to be independent. Managing symptoms in both knees requires a carefully balanced approach to ensure comfort and function on both sides.

How Arthrosamid Works: Delivering Balanced Relief in Both Knees

Arthrosamid is a gel made from polyacrylamide that is injected directly into the knee joint. It works by cushioning the joint surfaces and improving lubrication, helping to reduce pain and stiffness. A recent comprehensive review explains that Arthrosamid “adheres to and bulks up the synovial membrane and acts as a scaffold to treat the synovium,” which is the lining of the joint. This innovative approach provides a supportive environment within the knee to ease symptoms. The review also highlighted “statistically significant improvements at 52 weeks and beyond,” demonstrating Arthrosamid’s effectiveness even one year after treatment.

For those with bilateral knee OA, achieving equal relief in both knees is especially important to maintain balance and mobility. Arthrosamid can be injected into both knees, either in the same session or one after the other, to help optimise comfort and function across both joints. Professor Paul Lee, who has vast experience with complex orthopaedic cases, together with the team at MSK Doctors, offer expert, compassionate care in a professional setting to support patients throughout their treatment journey.

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Regaining Independence with Daily Activities and Gentle Exercise

With the improved joint comfort often experienced after Arthrosamid injections, many people find they can gradually return to their normal daily activities without as much pain. Regaining mobility is a crucial step towards restoring independence. Safe, low-impact exercises such as swimming, cycling or walking are ideal because they strengthen muscles around the knees while minimising strain on the joints.

It is important to adjust routines and fitness plans to protect both knees from overuse. Healthcare professionals at MSK Doctors provide personalised advice to help patients find the right balance. Encouragingly, the same review noted that “injection of PAAG hydrogel into the knee has been shown to be safe with no long-lasting adverse events reported,” giving patients confidence in this treatment as part of their long-term management plan.

Arthrosamid Compared to Corticosteroid Injections for Bilateral OA

Choosing the right treatment for bilateral knee OA can be challenging. Corticosteroid injections may offer quick pain relief but tend to be short-lived and unpredictable, especially when both knees are involved. In contrast, Arthrosamid provides longer-lasting and more consistent symptom control, which is highly beneficial when managing discomfort on both sides.

The review states clearly that “this PAAG hydrogel seems to be an efficacious and safe treatment option for knee OA, providing positive results for at least two years.” For people seeking reliable, symmetrical relief in both knees, Arthrosamid may offer clear advantages over traditional corticosteroid injections. Throughout this process, Professor Paul Lee and the MSK Doctors team use their expertise to help patients make informed treatment choices based on their individual needs.

Conclusion

Managing osteoarthritis in both knees effectively means treating both joints to improve mobility and daily comfort. Arthrosamid offers an innovative and promising option that supports these goals by providing sustained, balanced symptom relief. For those living with bilateral knee OA, consulting with experienced specialists such as Professor Paul Lee and the MSK Doctors team ensures personalised care and expert guidance throughout treatment and recovery. As always, please seek advice from a qualified healthcare professional for individual medical concerns.

References

Cole, A., Maulana, R. K., Whitehead, J. P., & Lee, P. Y. F. (2022). A systematic review of the novel compound Arthrosamid Polyacrylamide (PAAG) hydrogel for treatment of knee osteoarthritis. Medical Research Archives, 10(8). https://doi.org/10.18103/mra.v10i8.2950


Frequently Asked Questions

  • When both knees are affected by osteoarthritis, daily tasks like walking or climbing stairs become much harder. This significantly impacts independence and quality of life, making management of discomfort and mobility especially important for those with bilateral knee OA.
  • Arthrosamid is a hydrogel injected into the knee joint, cushioning surfaces and supporting the joint lining. This helps reduce pain and improve mobility, providing balanced relief to both knees, which is crucial for those dealing with symptoms in both legs.
  • Professor Paul Lee is internationally recognised as a cartilage expert and surgical ambassador. Together with the MSK Doctors team, he offers highly specialised treatment and compassionate care, ensuring every patient receives individual attention and the latest options for osteoarthritis management.
  • Research shows Arthrosamid delivers longer-lasting and more reliable symptom relief compared to corticosteroid injections. It is also regarded as safe, with no long-term adverse events reported, making it a promising choice for managing osteoarthritis in both knees.
  • By easing joint pain and stiffness, Arthrosamid allows many patients to gradually return to their normal routines. Under MSK Doctors’ expert advice, people often resume gentle exercise and daily tasks, supporting better mobility and an improved sense of independence.

Legal & Medical Disclaimer

This article is written by an independent contributor and reflects their own views and experience, not necessarily those of Lincolnshire Knee. It is provided for general information and education only and does not constitute medical advice, diagnosis, or treatment.

Always seek personalised advice from a qualified healthcare professional before making decisions about your health. Lincolnshire Knee accepts no responsibility for errors, omissions, third-party content, or any loss, damage, or injury arising from reliance on this material.

If you believe this article contains inaccurate or infringing content, please contact us at [email protected].

Last reviewed: 2026For urgent medical concerns, contact your local emergency services.

World-class orthopaedic surgeon

Professor Paul Lee

Consultant Cartilage Surgeon • Visiting Professor, University of Lincoln

CartilageHip & KneeSports InjuriesRegenerative Care
Fellowships
5
Publications
50+
Research grants
£100k+
Premier League exp.
Elite

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