25 Dec 2025
Arthrosamid vs Corticosteroid Injections for Bilateral Knee Osteoarthritis: Striving for Sustained Comfort and Everyday Function

Living with bilateral knee osteoarthritis – that is, osteoarthritis affecting both knees – can be especially tough. This condition causes the gradual wearing down of cartilage, leading to persistent pain and difficulty moving. For many people, this pain affects not only physical comfort but also everyday activities and the ability to plan ahead confidently. This article explores how Arthrosamid injections compare with corticosteroid injections in providing steadier, longer-lasting relief that supports everyday function. Drawing on clinical insights and recent research, we will look at how these treatments help people manage their symptoms and retain mobility over time.
Understanding the Treatment Options: Arthrosamid and Corticosteroid Injections
When it comes to treating osteoarthritis, Arthrosamid and corticosteroid injections offer different approaches. Corticosteroids are strong anti-inflammatory medicines injected into the joint to quickly ease pain by reducing inflammation. However, their relief tends to be short-lived, often requiring repeat treatments. Arthrosamid, meanwhile, is a synthetic gel designed to mimic the natural fluid in the knee joint that cushions and lubricates it. Unlike corticosteroids, Arthrosamid doesn’t break down joint tissues, making it a promising option for longer-term support. Understanding these differences is especially important for those with osteoarthritis in both knees, as they need treatments that provide consistent relief and allow them to keep moving comfortably.
The Importance of Long-Lasting Relief and Ongoing Support in Bilateral Knee Osteoarthritis
When both knees are affected, having treatment that provides sustained relief becomes vital. Persistent pain can interfere with simple pleasures like walking, working, looking after family, and socialising. Treatments that deliver longer-lasting effects reduce the highs and lows of pain, helping people plan their days with confidence and less disruption. Research supports this approach: a recent study found that Arthrosamid injections improved symptoms over 24 months, especially in older, non-diabetic patients with less severe osteoarthritis. This highlights the real-world benefit of treatments that maintain comfort and allow individuals to live more independently and actively.
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What Does the Research Say About Arthrosamid and Corticosteroids?
Recent studies offer valuable insights into how Arthrosamid compares with corticosteroids in managing knee osteoarthritis, particularly when both knees are involved. Arthrosamid tends to provide longer-lasting pain relief and better joint function over time, while corticosteroids often deliver faster but temporary symptom relief. Importantly, Arthrosamid’s gentle effect on joint tissues reduces the risk of further damage, a key consideration for long-term care. Regarding corticosteroids, a noteworthy study showed that while they offer strong short-term improvements, hyaluronic acid injections—a treatment somewhat similar to Arthrosamid—may provide more meaningful benefits in the long run. This finding reinforces the idea that immediate pain relief is valuable but lasting functional improvement is crucial for ongoing well-being.
The Value of Expert Guidance
Navigating treatment options for knee osteoarthritis can be complex. That’s why healthcare professionals such as Professor Paul Lee and the team at MSK Doctors are invaluable. With deep expertise in orthopaedics and rehabilitation, they provide personalised advice based on the latest evidence and individual needs. Their patient-centred approach helps you understand the benefits and limitations of treatments like Arthrosamid and corticosteroids, assisting you to make informed decisions tailored to your lifestyle and health goals.
Conclusion: Choosing the Right Treatment for Lasting Comfort
In summary, both Arthrosamid and corticosteroid injections offer important benefits for bilateral knee osteoarthritis, but they differ in how they work and the duration of relief they provide. Arthrosamid is well suited for those seeking longer-lasting support that helps maintain daily function, while corticosteroids may be preferred when short-term pain relief is needed. Given the individual nature of osteoarthritis, consulting experienced professionals such as Professor Paul Lee and MSK Doctors is essential to find the most suitable treatment plan. As always, personal medical advice is key—please speak to a qualified healthcare professional to explore your options.
References
Bensa, A., Bianco Prevot, L., Peretti, G., & Filardo, G. (2025). Effect of corticosteroids and hyaluronic acid injections on knee osteoarthritis trajectory. Journal of Experimental Orthopaedics, 12(3). https://doi.org/10.1002/jeo2.70333
Frequently Asked Questions
- Arthrosamid is a synthetic gel that cushions and lubricates the knee, offering longer-lasting relief, while corticosteroid injections provide quick, short-term pain relief by reducing inflammation. Unlike corticosteroids, Arthrosamid does not degrade joint tissues, supporting ongoing joint health.
- Long-lasting pain relief allows people with osteoarthritis in both knees to move more comfortably, enjoy daily activities, and plan with confidence. This reduces disruption from pain flare-ups and supports a more independent, active lifestyle, especially when both knees are affected.
- Professor Paul Lee and MSK Doctors have extensive orthopaedic experience and prioritise personalised, evidence-based care. Professor Lee, a cartilage expert and Royal College of Surgeons advisor, specialises in joint preservation and supports patients in making informed decisions tailored to individual needs.
- Professor Paul Lee is a recognised cartilage expert and serves as Regional Surgical Ambassador and Advisor to the Royal College of Surgeons of Edinburgh. His clinical leadership at MSK Doctors ensures patients benefit from the latest treatments and a patient-centred approach to knee osteoarthritis care.
- Studies show Arthrosamid injections can improve joint symptoms and function for up to 24 months, particularly in older, non-diabetic patients with less severe osteoarthritis. This research highlights longer-lasting benefits, making Arthrosamid a valuable option for people needing ongoing relief in both knees.
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This article is written by an independent contributor and reflects their own views and experience, not necessarily those of Lincolnshire Knee. It is provided for general information and education only and does not constitute medical advice, diagnosis, or treatment.
Always seek personalised advice from a qualified healthcare professional before making decisions about your health. Lincolnshire Knee accepts no responsibility for errors, omissions, third-party content, or any loss, damage, or injury arising from reliance on this material.
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