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A combination injection of autologous stem cells and a collagen scaffold achieved greater improvements in pain and function at two months than stem cells alone in patients with bone-on-bone knee arthritis.
Full-thickness cartilage lesions cannot self-repair; ChondroFiller, an injectable collagen scaffold, recruits the body's own cells to fill the defect without surgery.
Bone exposed at the joint surface defines Grade 4 cartilage loss; cartilage cannot repair itself without blood supply, so treatment branches between repair, realignment, or replacement based on whether damage is focal or diffuse, shaped by size, location, malalignment, age, and activity.
Damaged articular cartilage cannot repair itself because it lacks a direct blood supply. AMIC uses bone-marrow stem cells in a single operation; MACI requires a two-stage biopsy-and-culture approach—the choice determined mainly by defect size.
Two knee gel injections—Arthrosamid and ChondroFiller—demand entirely different aftercare: the former requires a protected 14-day integration window in the joint lining, whilst the latter needs three-phase physiotherapy spanning 12 weeks as the biodegradable scaffold guides cartilage repair throu...
An unloader brace applies outward valgus pressure to shift load away from worn medial knee cartilage during weight-bearing. A 4° correction reduces contact force by 46%, increasing to 82% at 8° of correction, with radiographic evidence of 0.3 mm joint space widening.
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Consultant Cartilage Surgeon • Visiting Professor, University of Lincoln
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